Last week, the Trump administration announced it was banning the use of human fetal tissue from some abortions in federally funded medical research.
The National Institutes of Health (NIH) said the policy would go into effect immediately and advance “science by investing in breakthrough technologies more capable of modeling human health and disease,” NIH director Dr. Jay Bhattacharya said in a statement.
Scientists told ABC News that research using human fetal tissue has contributed to understanding diseases better, such as HIV and Ebola, and helped in the development of some vaccines and drugs.
Changes at NIH give political appointees greater power to fund or block research
Some scientists worry the ban could prevent groundbreaking discoveries about the behaviors of certain diseases and stop the development of life-saving therapies.
“It’s not a scientific decision,” Dr. Lawrence Goldstein, a professor emeritus of cellular and molecular medicine at the University of California, San Diego, told ABC News. “It’s a moral decision that places the rights of fetal tissue that would be discarded above the rights of sick people who will benefit from that research.”
Dominic Gwinn/Middle East Images via AFP via Getty Images, FILE – PHOTO: In this Sept. 3, 2025, file photo, NIH Director Dr. Jay Bhattacharya speaks at the National Conservatism Conference in Washington, D.C.
How human fetal tissue has been used
Human fetal tissue has been used to study serious diseases and disorders, including AIDS, cancer, Parkinson’s disease, dengue, Ebola, hepatitis C, diabetes and spinal cord injuries.
Cell lines have been created from human fetal tissue that have led to the development of vaccines for rubella, rabies, chickenpox, shingles and hepatitis A. Research has also led to the development of drugs to treat HIV, hemophilia and sepsis.
President Donald Trump himself benefited from the research: the experimental antibody treatment he took to treat COVID-19 was developed using cells derived from human fetal tissue. At the time, Trump praised the treatment as a “cure.”
The tissue has been also used in reproductive medicine research to study fertility issues, pregnancy issues, and pregnancy conditions such as pre-eclampsia.
Goldstein said that human fetal tissue research also helps create humanized mouse models to study human immune systems.
“Using fetal tissue, you can make mice that have human blood-forming and immune systems,” Goldstein said. “And that’s valuable because a lot of the viruses that trouble human health don’t grow properly in mice. But if you can make mice with human blood and immune systems, those viruses will frequently grow, and you can learn how to make therapies to block them.”
Confusion at NIH as administration halts, then releases, billions of dollars for scientific research
There are very strict guidelines that researchers have to follow when using human fetal tissue, ensuring they are in compliance with federal and sometimes state requirements.
Additionally, the research must be reviewed and approved by the NIH’s Institutional Review Board (IRB), which specifically assesses federally funded research that uses human subjects.
The IRB assures that donation and reception of human fetal tissue were done with consent and not coercion and that there were no enticements provided to the participant, the clinic or the research team.
A researcher with knowledge of the matter, who asked that their name not be used due to fears of retribution, told ABC News that federal law states that donation cannot be even brought up to a pregnant individual deciding to terminate their pregnancy before the decision to terminate.
“These are extremely important guardrails that are in place to ensure that everything is handled properly,” the researcher with knowledge of the matter said.
Impacts of ending NIH funding
The Trump administration first instituted a ban ending all human fetal tissue research at NIH in 2019, but it was reversed by the Biden administration in 2021.
The current ban stops NIH funds from supporting all “grants, cooperative agreements, other transaction awards and research and development contracts,” the agency said in a statement.
Philip Cheung for The Washington Post via Getty Images, FILE – PHOTO: In this Nov. 15, 2019, file photo, mice used for fetal tissue research are kept in the vivarium mice room at the Biomedical Sciences Research Building at the UCLA campus in Los Angeles.
Some groups praised the Trump administration’s new policy, including the Independent Medical Alliance, a group that promoted unproven treatments during the COVID-19 pandemic.
“There is no ethical justification for performing experiments on tissue derived from aborted human beings,” Dr. Joseph Varon, president and chief medical officer of the Independent Medical Alliance, said in a statement. “The fact this practice continued for years within federally funded research institutions shows just how far removed parts of HHS had become from foundational medical ethics. This correction is long overdue.”
However, some scientists say the ban will affect ongoing and future work.
Dr. Anita Bhattacharyya, an associate professor of cell and regenerative biology in the school of medicine and public health at the University of Wisconsin-Madison, said she was hoping to apply for a future NIH grant to study human fetal tissue research and will now not be able to do so.
Bhattacharyya explained she currently uses human-induced pluripotent stem cells, which are reprogrammed cells that are similar to embryonic stem cells, in her work. However, the loss of NIH funding for human fetal tissue research could affect future work.
“My reaction was, ‘How are we going to do some of our research if we can no longer use human fetal tissue?'” she recalled to ABC News. “In particular, my lab studies Down syndrome and so we know that in Down syndrome, the brain develops differently to lead to the intellectual disability that people with Down syndrome have.”
Bhattacharyya said human fetal tissue is valuable when studying Down syndrome or neuropsychiatric disorders because it can recapitulate what’s happening in brain development.
“And so that’s where the human fetal tissue really provides us with a benchmark or the ground truth so that we can validate our models,” she said.
Finding alternative methods of funding is another issue, scientists told ABC News. The NIH was the largest funder of research involving human fetal tissue, and no longer financially supporting such research may leave scientists scrambling to find other donors.
Goldstein said there are private disease foundations that will sometimes fund human fetal tissue research, such as the California Institute for Regenerative Medicine, which funds stem-cell-related research in California.
NIH to spend $50M on autism cause studies, experts say US should focus on treatments
However, experts say the hole left behind by the lack of NIH funding cannot be made up through private donations.
“There’s really nothing adequate to substitute for the federal effort,” Goldstein said. “It is the largest funder of medical research in the United States. It has systems in place to regulate quality and ensure that ethics and scientific principles are being adhered to. We really can’t move ahead as efficiently as we would like with the absence of the NIH.”
Although the NIH said tissue from spontaneous abortions will still be available, the researcher with knowledge of the matter said this tissue is very often not suitable for research purposes.
“The reason is because, most often, spontaneous abortion happens as a result of some sort of genetic abnormality or some injury, infection, some kind of damage to the fetus itself, that renders that tissue completely unusable for scientific research,” they said.
“Additionally, because spontaneous abortions are just that, they’re spontaneous and therefore completely unpredictable,” the researcher continued. “We have to be very careful in the way that we handle that tissue. It makes those studies intractable. And so, for that reason, spontaneous abortions are not a suitable replacement for fetal tissue research that we would normally obtain.”
